The feasibility of an experimental model of donors after cardiac death in remote ischemic preconditioning studies for renal transplantation in porcine

To evaluate the feasibility of an experimental model of donors after cardiac death in remote ischemic preconditioning studies. METHODS: Twelve Landrace pigs were used as organ donors. They underwent cardiac arrest by coronary en block suture and interruption of ventilatory support. Haemodynamic data regarding the donor surgical protocol were evaluated. Studies variables included mean heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, central venous pressure and oxygen saturation and the time to death. RESULTS: Haemodynamic parameter indicated that the circulatory failure occurred after nine minutes of en block coronary suture and respiratory support interruption. The circulatory collapse occurred evenly across all groups. The heart rate and central venous pressure were statistically different between groups (p=0.023 and p=0.04), respectively. The remote preconditioning resulted in delayed time of death. CONCLUSIONS: The model is feasible, and was easily reproduced. The ischemic remote preconditioning tends to a slight increase in circulatory failure time.

Manejo da insuficiência renal aguda em cães e gatos / Manejo de la insuficiencia renal aguda en perros y gatos / Management of acute renal failure in dogs and cats

A insuficiência renal aguda (IRA) pode ser definida como perda da função renal de maneira súbita, provocando acúmulo de substâncias nitrogenadas. Diversas causas podem levar ao desenvolvimento de IRA em um animal, incluindo: choque grave, hemorragia intensa, hipotensão, desidratação, hipovolemia, anestesia profunda e nefrotoxinas. A fluidoterapia permanece como o fundamento do tratamento clínico da IRA nos animais. O objetivo terapêutico é normalizar o equilíbrio hídrico, resolver as inadequações hemodinâmicas e promover a formação de urina. O objetivo do presente trabalho é revisar sobre o manejo da insuficiência renal aguda em cães e gatos.

Acute renal failure (ARF) may be defined as a subtle loss of renal function, leading to accumulation of nitrogenated substances. Several causes may lead to the development of ARF in an animal, including severe shock, intense blood loss, hypotension, dehydration, hypovolemia, deep anesthesia and nephrotoxins. Fluid therapy remains the basis of ARF treatment in animals. Thee therapeutic objective is to normalize fluid balance, solve hemodynamic problems and promote urine production. The objective of the present study is to review the procedures to manage acute renal failure in dogs and cats.

La insuficiencia renal aguda (IRA) puede ser definida como pérdida de la función renal de manera súbita, causando acumulación de sustancias nitrogenadas. Varias causas pueden llevar al desarrollo de IRA en un animal, incluyendo: choque grave, hemorragia intensa, hipotensión, deshidratación, hipovolemia, anestesia profunda y nefrotoxinas. La fluidoterapia sigue siendo la base para el tratamiento clínico de IRA en los animales. El objetivo terapéutico es normalizar el equilibrio hídrico, resolver las inadecuaciones hemodinámicas y promover la formación de orina. El objetivo de este estudio es revisar sobre el manejo de la insuficiencia renal aguda en perros y gatos.